Contact Us

The University of Texas
Marine Science Institute
750 Channel View Drive
Port Aransas, TX 78373

Phone: 361-749-6711
Fax: 361-749-6777

Maps & Directions

ESBAUGH, ANDREW J

Andrew J Esbaugh

Assistant Professor
Department of Marine Science


Fish Physiology
a.esbaugh@austin.utexas.edu

Phone: 361-749-6835

Office Location
FAM

Postal Address
The University of Texas at Austin
Mar Sci Inst-Port Aran
750 Channel View Dr
Port Aransas, TX 78373

Ph.D., Queen’s University (2005)
B.Sc. Hon., Acadia University (2001)

Research Interests

Fish Physiology

Environmental physiology; respiratory gas exchange; acid-base and osmoregulatory balance; the evolution of physiological systems; aquatic toxicology.

In general, research in my lab focuses on the interaction between physiology and the environment in marine fish. In particular, my interest lies in the integrative roles of respiratory gas exchange, acid-base balance and osmoregulation, and how these systems are adapted to allow fish to thrive in a diverse array of environments.

One particular focus of my research involves understanding the evolution and mechanisms of respiratory gas exchange in water breathing animals. The successful uptake of oxygen and excretion of carbon dioxide are integral to all vertebrates, and in most modern teleost fish these processes are tightly linked via red blood cell proteins. However, the levels of the relevant components of red blood cells seem to vary widely among teleosts, and in more ancestral water breathers, such as sharks and hagfish, the red blood cell can be completely bypassed for carbon dioxide excretion. I am interested in deciphering the relative importance of various red blood cell proteins for gas exchange, as well as the evolutionary pressures responsible for driving carbon dioxide transport from the plasma into the red blood cells.

A second major focus of my research is looking at the potential for physiological systems to change in response to varying environments, both of natural and anthropogenic origin. Of particular interest are responses of fish to salinity changes related to evaporative water loss or freshwater inflow in the Gulf of Mexico, as well as the impacts of ocean acidification. This is of particular interest today due to the potentially damaging effects of global climate change and ocean acidification on fish populations.

A final area of research involves assessing the impacts of environmental toxins on fish survival, physiology and performance. Most recently I have been involved in examining the toxic effects of polyaromatic hydrocarbons on fish species in the Gulf of Mexico.

Current species of interest include red drum, summer flounder, spiny dogfish shark, toadfish and the Pacific hagfish.

Nys, C. Janssen, C.R., Mager, E.M., Esbaugh, A.J., Brix, K.V., Grosell, M., Stubblefield, W.A., Holtze, K. and De Schamphelaere, K.A. (in press). Development and validation of a abtioic ligand model for predicting chronic toxicitt of lead (Pb) to Ceriodaphnia dubia. Environmental Toxicology and Chemistry.

Esbaugh, A.J., Mager, E.M., Brix, K.V., Santore, R. and Grosell, M. 2013. Implications of pH manipulation methods for metal toxicity: not all acidic environments are created equal. Aquatic Toxicology 15:130-131.

Heuer, R., A.J. Esbaugh, and M. Grosell. 2012. Ocean acidification leads to counterproductive intestinal base loss in the gulf toadfish (Opsanus beta). Physiological and Biochemical Zoology 85:450-9.

Esbaugh, A.J., R. Heuer, and M. Grosell. 2012. The effects of future predicted levels of atmospheric CO2 on respiratory gas exchange and acid-base balance in the gulf toadfish, Opsanus beta. Journal of Comparative Physiology B 182(7):921-34.

Jeffrey, J.D., A.J. Esbaugh, M.M. Vijayan, and K.M. Gilmour. 2012. Modulation of the hypothalamo-pituitary-interrenal axis by social status in rainbow trout: the key players. General and Comparative Endocrinology 176(2):201-10.

Esbaugh, A.J., K.W. Brix, E.M. Mager, K.D. Schamphelaere, and M. Grosell. 2012. Multilinear regression analysis, preliminary biotic ligand modeling, and cross species comparison of the effects of water chemistry on chronic lead toxicity in invertebrates. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology 155(2):423-31.

Rodela, T.M., A.J. Esbaugh, D. Weihrauch, C. Veauvy, M.D. McDonald, K.M. Gilmour, and P.J. Walsh. 2012. Revisiting the effects of crowding and feeding in the gulf toadfish, Opsanus beta: the role of Rhesus glycoproteins in nitrogen metabolism and excretion. Journal of Experimental Biology 215(Pt 2):301-13.

Gilmour, K.M., S.F. Perry, A.J. Esbaugh, J. Genz, J.R. Taylor, and M. Grosell. 2012. Compensatory regulation of acid-base balance salinity transfer in rainbow trout (Oncorhynchus mykiss). Journal of Comparative Physiology B 182(2):259-74.

Brix, K.V., A.J. Esbaugh, K.M. Munley, and M. Grosell. 2012. Investigations into the mechanism of lead toxicity to the freshwater pulmonate snail, Lymnaea stagnalis. Aquatic Toxicology 106-107:147-156.

Guffey, S., A.J. Esbaugh, and M. Grosell, M. 2011. Regulation of apical H+-ATPase activity and intestinal HCO3- section in marine fish osmoregulation. American Journal of Physiology: Regulatory, Integrative and Comparative 301(6):R1682-91.

Rodela, T.M., A.J. Esbaugh, M.D. McDonald, K.M.Gilmour, and P.J. Walsh. 2011. Evidence for transcriptional regulation of the urea transporter in the gill of Gulf toadfish, Opsanus beta. Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biochemistry 160(2-3):72-80.

Brix, K.V. A.J. Esbaugh, and M. Grosell. 2011. The toxicity and physiological effects of copper on the freshwater pulmonate snail, Lymnaea stagnalis. Comparative Physiology and Biochemistry C: Toxicology and Pharmacology 154(3):261-7.

Esbaugh, A.J., K.V. Brix, E.M. Mager, and M. Grosell. 2011. Multi-linear regression models predict the effects of water chemistry on acute lead toxicity to Ceriodaphnia dubia and Pimephales promelase. Comparative Biochemistry and Physiology, Part C: Toxicology and Pharmacology 154(3):137-45.

Genz, J., A.J. Esbaugh, and M. Grosell. 2011. Intestinal transport following transfer to increased salinity in an anadromous fish (Oncorhynchus mykiss). Comparative Biochemistry and Physiology A: Molecular Integrative Physiology 159(2):150-8

Mager, E.M., A.J. Esbaugh, K.V. Brix, A.C. Ryan, and M. Grosell. 2011. Influences of water chemistry on the acute toxicity of lead to Pimephales promelas and Ceriodaphnia dubia. Comparative Biochemistry and Physiology C: Toxicology and Pharmacology 153(1):82-90.

Esbaugh, A.J. and P.J. Walsh. 2009. Identification of two glucocorticoid response elements in the promoter region of the ubiquitous isozyme of glutamine synthetase in the gulf toadfish, Opsanus beta. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 297(4):R1075-81.

Gilmour, K.M., K. Thomas, A.J. Esbaugh, and S.F. Perry. 2009. Carbonic anhydrase expression and CO2 excretion during early development in zebrafish Danio rerio. Journal of Experimental Biology 212(23):3837-3845.

Bayaa, M., B. Vulesevic, A.J. Esbaugh, M. Braun, M.E. Ecker, M. Grosell, and S.F. Perry. 2009. The involvement of SLC26 anion transporters in chloride uptake in zebrafish (Danio rerio) larvae. Journal of Experimental Biology 212(20):3283-95.

A.J. Esbaugh, K.M. Gilmour, and S.F. Perry. 2009. Membrane-bound carbonic anhydrase in the respiratory system of the Pacific hagfish (Eptatretus Stouti). Respiratory Physiology and Neurobiology 166(2):107-116.

Dhillon, R.S., A.J. Esbaugh, Y.S. Wang, and B.L. Tufts. 2009. Characterization and expression of a myosin heavy-chain isoform in juvenile walleye Sander vitreus. Journal of Fish Biology 75(5):1048-1062.

A.J. Esbaugh, S.F. Perry, and K.M. Gilmour. 2009. Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish (Danio rerio). American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 296(1):R150-160.

Ivanis, G. A.J. Esbaugh, and S.F. Perry. 2008. Branchial expression and localization of SLC9A2 and SLCA3 sodium hydrogen exchangers and their possible role in acid-base regulation in freshwater rainbow trout (Oncorhynchus mykiss). Journal of Experimental Biology 211(15):2467-77.

Esbaugh, A.J. and B.L .Tufts. 2007. Evidence for a carbonic anhydrase-related protein in the brain of rainbow trout (Oncorhynchus mykiss). Comparative Physiology and Biochemistry Part D 2(4):287-294.

Gilmour, K.M., R.M. Euverman, A.J. Esbaugh, L. Kenney, S.F. Chew, Y.K. Ip, and S.F. Perry. 2007. Mechanisms of acid-base regulation in the African lungfish, Protopterus anectens. Journal of Experimental Biology 210(11):1944-59.

Esbaugh, A.J. and B.L. Tufts. 2006. The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebrates. Respiratory Physiology and Neurobiology 154(1-2):185-198.

Esbaugh, A.J. and B.L. Tufts. 2006. Evidence of a high activity carbonic anhydrase isozyme in the red blood cells of an ancient vertebrate, the sea lamprey (Petromyzon marinus). Journal of Experimental Biology 209(7):1169-1178.

Esbaugh, A.J., S.F. Perry, M. Bayaa, T. Georgalis, J. Nickerson, B.L. Tufts, and K.M. Gilmour. 2005. Cytoplasmic carbonic anhydrase isozymes in rainbow trout Oncorhynchus mykiss: comparative physiology and molecular evolution. Journal of Experimental Biology 208(10):1951-1961.

Esbaugh, A.J., S.G. Lund, and B.L. Tufts. 2004. Comparative physiology andmolecular analysis of carbonic anhydrase from the red blood cells of teleost fish. Journal of Comparative Physiology B 174:429-438.

Esbaugh, A.J. and B.L. Tufts. 2004. Evidence for a membrane-bound carbonic anhydrase in the heart of an ancient vertebrate, the sea lamprey (Petromyzon marinus). Journal of Comparative Physiology B 174:399-406.

Tufts, B.L., A. Esbaugh, and S.G. Lund. 2003. Comparative physiology and molecular evolution of carbonic anhydrase in the erythrocytes of early vertebrates. Comparative Biochemistry and Physiology Part A 136:259-269.

Esbaugh, A.J., M. Hazel, and D.P. Toews. 2002. Aspects of lymph-heart function in Rana catesbeiana. Canadian Journal of Zoology 80:2125-2130.

BOOKS AND BOOK CHAPTERS

Perry, S.F., M. Braun, A.J. Esbaugh, and K.M. Gilmour. 2009. Gas transport and gill function in water breathing fish. In: Cardio-Respiratory Control in Vertebrates: Comparative and Evolutionary Aspects (eds. M.L. Glass and S.C. Wood) Springer, Berlin.

2011 - Best post-doctoral oral presentation (2011) Annual Meeting of the Canadian Society of Zoologists. Ottawa, Ontario, Canada. Presentation title "

2011 - Young Investigator Award (2011) International Conference for Comparative Biochemistry and Physiology. Nagoya, Japan.

2009 - Inside Journal of Experimental Biology article (2009) for paper titled "Carbonic anhydrase expression and CO2 excretion during early development in zebrafish Danio rerio."

2007 - Journal of Experimental Biology Annual Highlights (2007) for paper titled "Mechanisms of acid-base regulation in the African lungfish, Protopterus anectens."

Esbaugh, A.J., E. Mager, J. Stieglitz, R. Hoenig, J. Incardona, N. Scholtz, D. Benetti, and M. Grosell. 2012. Acute toxicity and cardiac impairment of Deepwater Horizon oil on two pelagic fish species native to the Gulf of Mexico. Annual meeting of the Society of Environmental Toxicology and Chemistry. Long Beach, California, USA.

Esbaugh, A.J., R. Heuer, and M. Grosell. 2011. The physiological response of predicted future levels of atmospheric carbon dioxide on respiratory gas exchange and acid-base balance in the gulf toadfish. Annual Meeting of the Canadian Society of Zoologists. Ottawa, Ontario, Canada.

Esbaugh, A.J., R. Heuer, and M. Grosell. 2011. The physiological response of predicted future levels of atmospheric carbon dioxide on respiratory gas exchange and acid-base balance in the gulf toadfish. International Conference of Comparative Biochemistry and Physiology, Nagoya, Japan.

Esbaugh, A.J., K. Brix, E. Mager, and M. Grosell. 2009. Validation study for the acute and chronic biotic ligand models for lead. Annual Meeting of the Society of Environmental Toxicology and Chemistry. New Orleans, Louisiana, USA.

Esbaugh, A.J., K.M. Gilmour, and S.F. Perry. 2008. Membrane-associated carbonic anhydrase in the respiratory system of the Pacific hagfish (Eptatretus stouti). The International Congress on the Biology of Fish. Portland, Oregon, USA.

Esbaugh, A.J., S.F. Perry, and K.M. Gilmour. 2007. Identification and characterization of hypoxia-inducible carbonic anhydrase IX in zebrafish, Danio rerio. The Annual Meeting of the Canadian Society of Zoology. Montreal, Quebec. Canada.

Esbaugh, A.J., R.H. Euverman, L. Kenney, S.F. Chew, Y.K. Ip, S.F. Perry, and K.M. Gilmour. 2006. Acid-base balance in the African lungfish (Protopterus annectens). The International Fish Congress, St. Johns, Newfoundland. Canada.

Esbaugh, A.J. and B.L. Tufts. 2005. The molecular evolution and comparative physiology of cytoplasmic carbonic anhydrase in an ancient vertebrate, the lamprey (Petromyzon marinus). The Annual Meeting of the Canadian Society of Zoologists, Kingston, Ontario. Canada.

Esbaugh, A.J., S.F. Perry, M. Bayaa, T. Georgalis, J. Nickerson, B.L. Tufts, and K.M. Gilmour. 2004. Identification and comparison of cytoplasmic carbonic anhydrase isozymes from the erythrocytes and gills of rainbow trout, Oncorhynchus mykiss. The Annual Meeting of the Canadian Society of Zoologists, Wolfville, Nova Scotia. Canada

Esbaugh, A.J. and B.L. Tufts. 2002. Carbonic anhydrase isozymes in primitive vertebrates. The Rice Lake Fish Workshop, Rice Lake, Ontario. Canada.

Esbaugh, A.J. and B.L. Tufts. 2002. Carbonic anhydrase isozymes in ancient vertebrates. The Annual Meeting of the Canadian Society of Zoologists, Lethbridge, Alberta. Canada.

INVITED PRESENTATIONS

Esbaugh, A.J., S.F. Perry, and K.M. Gilmour. 2007. Identification and characterization of hypoxia-inducible carbonic anhydrase IX in zebrafish, Danio rerio. The 2007 Annual Ottawa Carleton Integrative Biology Conference. Ottawa, Ontario, Canada.

POSTER PRESENTATIONS

Esbaugh, A.J., E.M. Mager, K.V. Brix, and M. Grosell. 2011. The physiological implications of pH manipulation methods and their impact on observed toxicity. The Annual Meeting of the Society of Environmental Toxicology and Chemistry. Boston, Massachusetts. USA.

Esbaugh, A.J., R. Heuer, and M. Grosell. 2011. The physiological response of predicted future levels of atmospheric carbon dioxide on respiratory gas exchange and acid-base balance in the gulf toadfish. Annual Meeting of the Canadian Society of Zoologists. Ottawa, Ontario, Canada.

Esbaugh, A.J. and P.J. Walsh. 2008. Cortisol-mediated expression of glutamine synthetase in the Gulf toadfish, Opsanus beta: A genomic DNA perspective. The International Congress on the Biology of Fish. Portland, Oregon, USA.

Esbaugh, A.J., S.F. Perry, and K.M. Gilmour. 2007. Identification and characterization of hypoxia-inducible carbonic anhydrase IX in zebrafish, Danio rerio. The Rice Lake Comparative Physiology Workshop. Rice Lake, Ontario, Canada.

Esbaugh, A.J., S.F. Perry, and K.M. Gilmour. 2006. Identification and characterization of hypoxia-inducible carbonic anhydrase IX in zebrafish, Danio rerio. The 7th International Conference on the Carbonic Anhydrases. St. Augustine, Florida, USA.

Esbaugh, A.J. and B.L. Tufts. 2005. Evidence for a carbonic anhydrase-related protein in the brain of rainbow trout, Oncorhynchus mykiss. The Annual Meeting of the Canadian Society of Zoologists. Canada.

Esbaugh, A.J. and B.L. Tufts. 2003. The evolution of red blood cell carbonic anhydrase: properties of red blood cell carbonic anhydrase in a teleost fish, Oncorhynchus mykiss. The Annual Meeting of the Canadian Society of Zoologists, Waterloo, Ontario. Canada.

*presenting author presentations and posters only.

Undergraduate

MNS 355C: Physiology of Fishes

GRADUATE STUDENTS & POSTDOCTORAL SUPERVISION

Graduate Students

Elizabeth Brown

Postdoctoral Fellows/Visiting Scientists/ International Students

Wiolene Nordi; Visiting Doctoral Student from Universidade de Sao Paola